15,000+++ Health Professionals On Covid / Covid_19, Covid-19, Cornavirus 19 - Well Researched Posts

Discussion in 'OFF TOPIC SUBJECTS' started by CULCULCAN, Mar 11, 2021.

  1. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    9b288ba637af86ea.
     
  2. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    What did President Donald J. Trump
    @realdonaldtrump WANT US TO SEE
    VIDEO - ATTACHED
    @dacase www.gettingtrump.com
    @iLDonaldOTrumpO @JohnDurham
    @hsretoucher @love17andyahweh

    Trump Video
    (trumpvideo3.mp4) attaached
     

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  3. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    The Vaccine Trials Documentary: Pfizer Knew 1,291 Side Effects, 1,205,753 Adverse Events ...

    https://rumble.com/v10aqux-the-vacc...fects-1205753-advers.html?mref=7ebcl&mc=9dvkh
    f30071fa46a6caaf.
    The Vaccine Trials Documentary: Pfizer Knew 1,291 Side Effects, 1,205,753 Adverse Events…
    The Vaccine Trials Documentary: Pfizer Knew 1,291 Side Effects, 1,205,753 Adverse Events…
    Now the truth is unfolding March 2022, Pfizer Covid vaccine has 1,291 side…
     
  4. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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  5. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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  6. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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  7. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro

    liji-thomas. By Dr. Liji Thomas, MDJan 14 2021
    As the coronavirus disease 2019 (COVID-19) pandemic continues to infect people worldwide, specific pharmaceutical interventions have been found to be few. As the logistics of mass vaccination are still being ironed out, most public health measures across the globe still largely involve non-pharmaceutical interventions (NPIs) such as physical distancing, hand and face hygiene, mask-wearing, isolation of infected people and tracing of contacts.
    Now, an interesting new study appearing on the bioRxiv* preprint server reports the virucidal and fusion-inhibiting attributes of snake venom against the COVID-19 agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    shutterstock_177232694.
    Study: Snake venom phospholipases A2 possess a strong virucidal activity against SARS-CoV-2 in vitro and block the cell fusion mediated by spike glycoprotein interaction with the ACE2 receptor. Image Credit: Dmitri Gomon / Shutterstock
    Snake venom as a source of virucidal compounds

    Snake venom has been reported to contain compounds with multiple physiological activities, including antibacterial, antifungal, antiparasitic and antiviral properties. The current study explores one component of snake venom, the secreted phospholipase A2 enzymes (sPLA2s), which have a wide range of diverse sequences and biological functions. These are primarily involved in lipid metabolism and signaling pathways.
    Variation in PLA2 activity

    PLA2s are small secreted protein enzymes that facilitate the hydrolysis of membrane glycerophospholipids to lysophospholipids and free fatty acids. For instance, some of these enzymes may break down the envelope lipid bilayers by hydrolyzing the phospholipids. Others may be unable to do so.
    An earlier study on dimeric PLA2 crotoxin, from Crotalus durissus terrificus, and its active subunit PLA2-CB, were able to inactivate dengue virus type 2, among other viruses, by splitting the glycerophospholipids of the virus envelope. However, these toxins did not affect Coxsackie B5 and encephalomyocarditis virus, which lack a lipid envelope. They were also inactive against viruses that bud through the plasma membrane.
    The virus envelope can have varying composition, depending on the origin of the lipids – from the plasma membrane or the endoplasmic reticulum membrane. This can affect the activity of the PLA2, suggesting that the phospholipid breakdown caused by these enzymes mediates their antiviral effects.
    Dimeric PLA2 suppresses viral replication

    The researchers found that sPLA2s act against SARS-CoV-2 in vitro, particularly group IIA dimeric PLA2s. When the virus was treated with the two dimeric PLA2s HDP-1 and HDP-2, strong virucidal activity was observed to result. This was observed as suppression of the cytopathic effect (CPE) expected as a result of viral infection of cell cultures.
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    Such inhibition was observed even at low concentrations (0.1 μg/ml). The active subunit of HDP-2 (HDP-2P) is twice as active as the whole enzyme. This was inhibited by the presence of the PLA2 inhibitor, 4-bromophenacyl bromide, which acts by modifying the active center His residue.
    An earlier study of cobra group IA PLA2 CM-II showed no virucidal properties when tested against the related pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV). This may be explained by the genetic and structural differences between this virus and SARS-CoV-2, such as the 70% divergence in their spike (S) glycoproteins. If this is the case, different groups of PLA2s can affect the virus in a varying manner.
    Inhibition of cell fusion

    The researchers also found that at concentrations varying between 1 to 100 μg/ml, both dimeric HDP-1 and HDP-2 inhibited spike-mediated syncytia formation, thus hindering the virus's spread between cells. While there was about 70% inhibition at 100 μg/ml, it was reduced to about 48% at 1 μg/ml. Notably, the active subunit HDP-2P completely blocked the cell-cell fusion at 100 μg/ml. This could indicate that they can prevent viral entry into cells, one more possible mechanism by which they prevent viral infection of host cells.
    The hydrolysis of membrane phosphatidylcholine by PLA2 generates lysophosphatidylcholine, a known inhibitor of the membrane fusion caused by viruses like influenza, rabies and simian influenza viruses. This activity can prevent the entry of the virus into the host cells.
    Weak effect on cell viability

    The study also showed a weak effect on cell viability, as shown by reduced cell proliferation. The anti-proliferative and cytotoxic effect of PLA2s reported in earlier studies is directed against cancer cells, mainly, and not normal cells. Moreover, the PLA2s studied here were used at very low concentrations, orders of magnitude lower than that required to produce an effect on normal cells. This lends value to the concept of using these enzymes to produce antivirals, as well as to study how viruses interact with host cell membranes.
    The researchers also found some degree of similarity between the S protein of SARS-CoV-2 and the dimeric PLA2s, especially the spike segment that interacts with the host cell ACE2 receptor. This may indicate that dimeric PLA2s competitively inhibit viral binding to ACE2. More research will be required to elucidate the real mechanism by which the PLA2s block syncytia formation mediated by the spike glycoprotein.
    Conclusion

    Summarizing previous and our findings on the ability of snake PLA2s to inactivate various viruses, these results highlight the potential of PLA2s as a natural product for the development of broad-spectrum antiviral drugs."​
    Not only so, these drugs, which act specifically on the lipid bilayer of the viral envelope, offer an excellent method to understand how viruses attack the host cell membranes, from which their lipids are derived.
    *Important Notice

    bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
    Journal reference:
     
  8. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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  9. CULCULCAN

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    Implications for Snake Venom's Role in the "Covid-19 Pandemic"


    https://rebeccaweaver.substack.com/p/implications-for-snake-venoms-role
    2022-04-12 · If you haven’t seen “Watch the Water” yet with Stew Peter’s interviewing Dr. Bryan Ardis (4/11/22) regarding his theory and research on snake venom as the primary culprit

    Implications for Snake Venom's Role in the "Covid-19 Pandemic"

    If this is true, it changes how we view everything.

    adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7e2bb4c4-07e3-4f79-87f0-eeb6e65f8e8f_2048x2048.
    Rebecca Weaver
    16 hr ago
     5 
    If you haven’t seen “Watch the Water” yet with Stew Peter’s interviewing Dr. Bryan Ardis (4/11/22) regarding his theory and research on snake venom as the primary culprit in this Covid charade, I recommend you start there.
    The implications of this theory proving correct may help provide a new lens for reviewing the last two years and guide us going forward. But should you remain incredulous, I understand there will more interviews and data forthcoming, to further corroborate this theory. One such source will be the The Dr. Ardis Report, where we’re told they will provide interviews and more science in the coming weeks.
    UPDATED: This is Biblical – Dr. Bryan Ardis Walks You Through His Months Long Journey to Corroborate his Covid-19 Snake Venom Theory. A Must Watch
    When I first heard whispers of this last week, I was very skeptical. I began some research of my own on the chemical compounds and processes of snake venom. It was fascinating and revealing. I had also heard anecdotal stories of a substance called Methylene Blue (Methylthioninium chloride) working effectively to treat Covid-19. As I was able to write and edit a few pieces on this substance over the last few months, I remembered reading that Methylene Blue was FDA approved to treat poisoning from snake venom and is also listed for poison treatment on the WHO Essential Medicines List.
    This begged the question, “why would a medicine, used to treat acute hypoxia due to poisoning, be effective against a ‘respiratory virus,’ when all the usual respiratory cocktails, including oxygen therapy, steroids, and ventilators so often were not?” The answer had to be an interesting one. In fact, the answer that Covid-19 is a poison delivered through the vector of a fairly harmless corona virus (modified to infect humans in the early 2000s), actually makes quite good sense. So, you see, I was already prepared to believe.
    -adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa5432bad-0518-4109-a8a5-44f16c50b597_1026x567.

    Hearing Dr. Ardis suggest this venom has an innate disease targeting skill whereby the weakest link in our body’s organs or health structures get targeted first and thus helps cloak the real cause of death (poison), makes you realize how genius nature is. Nature, naturally, intended for the snake venom to most quickly paralyze and begin to break down the prey for the snake’s consumption, or provide a rapid defense from a predator.
    I cannot speak to the genius of the creators of these poison cocktails, but they are clearly pure evil. The ability to kill someone and give the appearance they have died of a disease they were predisposed to is quite insidious. A mild diabetic that suddenly dies of pancreatic or kidney failure, the cancer patient in full remission that dies of massive acute onset, etc.
    Looking forward, currently, we’re being told that some cities are reinstating their indoor masking requirements. They are seeing “fresh outbreaks of COVID,” such as Philadelphia. Many well-known Democrats, fully vaccinated and boosted, are sharing their latest Covid positive results, their gratitude for their vaccine and boosters, and their scripted urgings for you to get yours. It’s as though they want to lend credibility to the narrative that the new outbreak is quite real.
    Well, if Covid illness (we all know the tests are bogus) comes from the treatments such as Remdesivir, the vaccines (gene therapies), and the water supply, this must mean these new cases in targeted areas are just that, targeted. Therefore, “who benefits,” should be our new mantra.
    What is going on, for example, in Philadelphia currently? Are there fresh and compelling allegations of election fraud? Do they want to prevent a jury from assembling? Is there an important vote coming up that they need to ensure only mail-in ballots can be used? Who knows?
    Are there states across the country headed to the voting booths with certain demise in store for globalist candidates? Could they use targeted water supply treatment to create outbreaks and shutdown the very systems that would prevent them from succeeding in their 2022 voting charade? The FDA’s approval for outpatient and early patient treatment with Remdesivir will result in a new spike in the death count. They now offer this poison to babies 7 lbs. or more that simply test positive for Covid. They will take ever younger lives to help build their fear mongering narrative and sell their vaccines to the parents of children and newborns.
    And what of the past two years. Were they cautiously restoring freedoms only to be “right all along” and pull them back in the wake of a new “variant?” Each time, training us how to peacefully relinquish our freedoms in the service of “the greater good,” and be thankful for their wise guidance?
    Was the well timed Covid-19 2020 Pandemic introduced to destroy the robust economy and prevent Trump’s reelection? Was it meant to usher in all mail-in balloting and enable CTCL (Center for Tech and Civil Life) to provide Ballot Drop Boxes (open for weeks) with often no oversight or chain of custody, and massive counting centers where midnight drop-offs could be made to offset the margin? Bringing in their own staffing to count ballots and man the technically complex new voting systems, leaving the community volunteers out in the cold, while demanding six feet of space for poll watchers often placing them 100s of yards away from any actual vote counting tables, all in the name of COVID.
    Could the Daily Cuomo Panic Pressers of 2020 all have been a dramatic charade to cajole you into accepting your obvious fate. States of Emergency declared in nearly every state, regardless of disease, due primarily to the daily reminder that “our states were next.” All voting normality thrown out the window for the greater good.
    Could it be NY and NYC, in particular, were targeted due to the large, publicly funded hospital care systems and the very dense population ill-prepared to advocate for their family members? A perfect target for maximum impact (implementation of an untested NIH deadly protocol) with minimum input into the water system. Draconian lockdowns with new rules that destroyed businesses, rents, homes, lives and education, all to sell the illusion of an election outcome that was highly unlikely?
    And what can be done about it now? Now that many realize that this mRNA gene therapy can, in fact, change your DNA through a process called reverse transcriptase and one may be left producing low levels of spike protein indefinitely. And more importantly, their DNA may be permanently altered and would likely pass down to their children should they be lucky enough to have any. Not to mention the seemingly irreparable harm we’re learning this may have on immune systems. The jab’s silencing of the p57 tumor suppressing gene and the vigilant toll-like receptors 4, 7 and 8 invite all manner of chronic disease to make their home in our bodies, long or short term, whichever comes first.
    Obviously, like any poison, the more of it you get, the worse your symptoms and outcome. Hence the boosters?
    Do your research, take your vitamins, strengthen your immune system and stay away from pharmaceuticals and the doctors and hospitals that peddle them, as much as you possibly can.
    It’s time to widen our health and wellness gaze. Things that we've been conditioned to label as “alternative” or “quackery” are very likely the real medicine. At the end of the interview, they list additional medicines that are effective against this poison. They are likely some you’ve heard of already. There is hope.
    Learn more about this topic and other resources at Hands for Health and Freedom.
    And please, stay safe out there!
    Rebecca


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    By Rebecca Weaver · Launched 3 months ago
    Applying a fresh lens to current events and history. Exploring theories and actions to safeguard our freedoms. They are counting on our ignorance and apathy. We must educate and organize ourselves. Freedom demands that we show up!
     
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